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Kidney Disease Hospital

This page is intoduction Kidney Disease such as:

chronic kidney disease

Chronic kidney disease (CKD) refers to conditions that damage your kidneys and decrease their ability to keep you healthy by doing the jobs such as regulating the balance of water and electrolyte, discharging metabolic waste and secreting hormones essential to human body.

If kidney disease gets worse, metabolic wastes can accumulate to high levels in your blood and make you feel sick. You may present complications like edema, high blood pressure, anemia, proteinuria, hematuria, respiratory tract problem, gastrointestinal tract disorder and nerve problems. In addition, kidney disease increases your incidence of having heart and blood vessel disease. These problems may emerge slowly over a long period of time.

Chronic kidney disease may be aroused by diabetes, elevated blood pressure and other disorders. Early detection and treatment is advisable and helpful to prevent chronic kidney disease from getting worse. When kidney disease progresses, it may eventually lead to renal failure, which requires dialysis or a kidney transplant to 　replace your original damaged kidneys.

chronic kidney disease does not show obvious symptoms in the early stages, because kidney is such a particular organ that it has a very qualified compensatory ability. Each kidney has more than 100 million nephrons which is the basic point. Given some nephrons damaged, the rest and healthy nephrons can still sustain the normal running of your kidneys, so you can not realize you have got chronic kidney disease. If other healthy nephrons get imposed on too much burden over time, they can also get injured due to overworking. Consequently, a series of symptoms come across, for instance, Edema in general body, Lumbago, Elevated Blood Pressure, Anemia, Anuria and enuresis nocturna.

Usually, patients can go to the hospital for urine routine test, blood routine test and renal functional examination. Nephrotic physicians diagnose your disease through checking these watershed indicators, such as Serum Creatinine, Urea Nitrogen, GFR, urine specific gravity, erythrocyte and leukocyte. In usually cases, the level of serum creatinine does not present bumpy, even though a part of renal function go haywire. However, your renal function is virtually impaired when the level of serum creatinine hikes suddenly. Combining with GFR and other indicators, the doctor’s diagnosis will be more reliable.

Many patients would resort to hemodialysis and kidney transplant when they are in the end stage of Chronic Kidney Disease. Actually Dialysis is effective and necessary to remove metabolic waste and toxin in human body, but patients is probably to addict dialysis. Long term of dialysis will replace the original kidney and they can become atrophy day by day because of Ischemia and Anoxia of kidney blood vessels. Micro-Chinese Medicine can promote blood circulation so as to relieve kidney’s ischemia and anoxia. Renal fibrosis can be blocked and even restored through treatment. Kidney Transplant has a high successful rate of surgery, but its survival rate is bleak and uncontrolled. Patients must be prudent to prevent rejection and inflammation, a small cold would let renal fail. We use stem cell transplant which can differentiate into various tissues and organs according to our requirement. This kind of cell has qualified homing ability, and it can reach damaged area and grow into blood cells and tissue. Moreover, it is transfused into human body through intravenous injection and does not need matching at all, therefore this approach is very superior to kidney transplant in terms of safety and convenience.

polycystic kidney disease

Polycystic Kidney Disease (PKD), also called Potter syndrome or Perlman syndrome, is a genetic disorder, which can be divided into Autosomal Dominant Polycystic Kidney Disease (ADPKD) and Autosomal Recessive Polycystic Kidney Disease (ARPKD). ARPKD can be diagnosed typically in the first few weeks after birth and the children are usually unable to live out their childhood. So we mainly talk about ADPKD here.

Causing genes

The Autosomal Dominant Polycystic Kidney Disease is caused by two genes: ADPKD1 and ADPKD2. ADPKD1 lies in the short arm of chromosome 16, while ADPKD2 is located on the short arm of chromosome 4. As is reported, patients with ADPKD2, especially the female patients, tend to have less severe ill conditions than patients with ADPKD1. The signs or symptoms of ADPKD1 like kidney function declining or renal failure may appear later than that of people with ADPKD2. ADPKD2 is responsible for 90% cases of Autosomal Dominant Polycystic Kidney Disease. With autosomal dominant inheritance, there is a 50% chance that the disease will pass to the children of one patient with PKD.

The general course

Patients are born with cysts which are too small to check out. At their twenties, cysts usually have began to grow but without any visible or perceptible symptoms. When patients reach their thirties or forties, cysts in their kidneys will get bigger shapely. Blood pressure becomes slightly high among those patients, which can further speed up the deterioration of PKD. After about ten years of high blood pressure, namely at their forties, patients will have the tumid cysts and severe symptoms occur such as hemature, proteinuria and flank pain. The renal function begins to fail. After the age of fifties, PKD will cause real insufficiency or renal failure as well as cysts in liver and other organs. The severe complications will also occur such as cerebral aneurysm and heart diseases, which take the main responsibility for the death of patients with PKD.

Clinical symptoms

If PKD is on exertion, flank pain and high blood pressure are its first symptoms. Flank pain is persistent or paroxysmal, which will become severe after tiredness. With high blood pressure, patients may have headache and dizziness. Patients can feel the cysts when they touch their back or waist. About half of patients with PKD will have hematuria and one fourth of the patients show renal colic, frequent urination and urgent urination. In late stages of PKD, renal insufficiency or Kidney Failure comes up with their severe symptoms.

renal failure

In general, Renal Failure means part or complete loss of renal function which is caused when various chronic kidney diseases develop into the end stage. In clinical, Renal Failure can be divided into four stages according to the degrees of renal damage and creatinine index.

1. Compensatory Period: In this stage, the glomerular filtration rate (GFR) is 50-80 mL/min. The creatinine clearance rate (CCR) decreases but is higher than 50 mL/min. Serum creatinine (Scr) is lower than 178μmol/L and blood urea nitrogen (BUN) is lower than 9mmol/L.

2. Discompensatory Period: This stage is also called Azotemia Period. In this stage, the creatinine clearance rate (CCR) is 25-50 mL/min, serum creatinine rises higher than 178μmol/L (2mg/dL) and blood urea nitrogen (BUN) is higher than 9 mmol/L (25mg/dL). There is no obvious discomfort except mild anemia, some symptoms in digestive tract and nocturia increased.

3. Renal Failure Period: In this stage, the creatinine clearance rate (CCR) is 10-25mL/min, serum creatinine is 221-442μmol/L and blood urea nitrogen is 17.9-21.4 mmol/L. In this stage, the kidneys still have certain function, which is called early stage of Uremia.

4. Uremia Period: In this stage, Scr is 442μmol/L and BUN is higher than 21.4mmol/L. There usually appears variety of symptoms of Uremia, such as apparent anemia, serious nausea, vomiting, and various complications of the nervous system, even coma, obvious disorder of water and salt metabolism and acid-base balance, oliguria or anuria. When the creatinine clearance rate (CCR) is lower than 10ml/min and serum creatinine is higher than 707μmol/L, it enters the end stage, which is also called the end stage of Uremia.

There are two types of Renal Failure: acute and chronic. Acute Renal Failure occurs suddenly and is usually initiated by underlying causes, for example dehydration, infection, serious injury to the kidney or the long-term use of over the counter pain medications like Tylenol (acetaminophen) or Advil (ibuprofen). Acute Renal Failure is often reversible.

Acute Renal Failure is a sudden decline of the kidney functions, indicated by a high buildup of toxins in the blood. If kidneys cannot function, they cannot filter the toxins out of body. Therefore, toxins begin to build up in the body, affecting the kidneys and other organs. There are three types of Acute Renal Failure--Prerenal, Intrinsic and Postrenal. Different types of Acute Renal Failure have different symptoms.

stem cell transplant kidney disease

Stem cells are the original cells of human body which has the ability of self-renewing and multiple differentiation of other tissues. As we know, the body derives from one oosperm. Because oosperm has the whole set of genes and are the most original cells which can differentiate all the tissues and cells of the body. Oosperm is the most advanced stem cell . In certain conditions, stem cells can differentiate the necessary cells which are used by people to treat some diseases, like Chronic Kidney Disease.

1) Obvious treatment effects. Due to the powerful ability of self-renewing and multiple differentiation, stem cells can treat diseases from the root causes, repairing the damaged cells and recovering the normal cells. Therefore, it can prevent the relapse of disease. stem cell transplant can better symptoms fundamentally.

2) No pain. Stem cells transplant is very different from kidney transplant and heart transplant. Stem cells are just injected by vein without any surgery.

3)No rejection reaction. Because stem cells are the original cells of the body, the surface antigen is not obvious and is not easy to be recognized by antibody. Therefore, after stem cell transplant, there is no rejection reaction as kidney transplant. Patients needn't take immune-suppression drugs.

4) Adequate source of stem cells. There are amounts of stem cells in the body. Stem cells are easy to separate, cultivate and purify. The daughter cells have the same features as mother cells.

5) The new cells differentiated by stem cells are the totally same as the normal cells of the body. These new cells still have physiological functions after many generation.

6) Homing ability( targeted position). The signals of the damaged cells or organs can stimulate stem cells to reach to the damaged organs. Stem cells take homing to the lesion and repair the damaged cells.

Kidney Disease Hospital

Shijiazhuang Kidney Disease Hospital locates in Shijiazhuang City, Hebei Province, China. The hospital was established in 1986, and it has become one of the most professional nephropathy treatment institutes in China.

Shijiazhuang Kidney Disease Hospital occupies more than 6 acres. The building area is about 48,000 square meters, with more than 1200 hospital beds. Micro-Chinese Medicine Osmotherapy (hereafter referred as MCMO) is the most featured treatment method of Shijiazhuang Kidney Disease Hospital. Combined with Stem Cells Transplantation and Hemodialysis and Immunosorption techniques, the MCMO makes a real difference in treating Nephropathy. The application of MCMO overthrows the pessimistic verdict that nephropathy can only be treated by dialysis or other alternatives that help with excreting toxin of the body.

These three treatments have proven to be effective after years of clinical application. And hundreds of thousands of patients have benefited from these therapies.

Shijiazhuang Kidney Disease Hospital adopts subdiscipline-treatment method for different nephropathy patients; it has now 29 inpatient areas and one stem cells transplantation centre. There are inpatient areas of nephritis, nephritic syndrome, renal failure, uremia, renal cyst, diabetic nephropathy, purpura nephritis, nephrotuberculosis, kidney rehabilitation, etc.

Due to more and more consultants from abroad, Shijiazhuang Kidney Disease Hospital set up an International Department in order to provide foreign patients with high-quality services. Stuffs of this department speak English fluently and know well about kidney diseases. Working together with nephrologists, International Department will provide every foreign patient with effective treatment as well as comfortable living here.

In recent years, Shijiazhuang Kidney Disease Hospital took part in many charity medical aid activities; it has provided free treatments for the children with kidney diseases, most of them from poor families or social welfare institutes.

As the only Kidney Disease special Hospital in Hebei Province, Shijiazhuang Kidney Disease Hospital ,in cooperation with the Provincial Medical Association，Municipal Medical Association ,has played a great role in the popularization of Kidney Disease knowledge.

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